Functional Divergence and Horizontal Transfer of Type IV Secretion Systems
نویسندگان
چکیده
منابع مشابه
Functional divergence and horizontal transfer of type IV secretion systems.
The type IV secretion system (TFSSs) is a multifunctional family of translocation pathways that mediate the transfer of DNA among bacteria and deliver DNA and proteins to eukaryotic cells during bacterial infections. Horizontal transmission has dominated the evolution of the TFSS, as demonstrated here by a lack of congruence between the tree topology inferred from components of the TFSS and the...
متن کاملType IV secretion systems: tools of bacterial horizontal gene transfer and virulence
Type IV secretion systems (T4SSs) are multisubunit cell-envelope-spanning structures, ancestrally related to bacterial conjugation machines, which transfer proteins and nucleoprotein complexes across membranes. T4SSs mediate horizontal gene transfer, thus contributing to genome plasticity and the evolution of pathogens through dissemination of antibiotic resistance and virulence genes. Moreover...
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This paper reports an analysis of the functional interactions between type IV secretion systems (T4SS) that are part of the conjugative machinery for horizontal DNA transfer (cT4SS), and T4SS involved in bacterial pathogenicity (pT4SS). The authors' previous work showed that a conjugative coupling protein (T4CP) interacts with the VirB10-type component of the T4SS in order to recruit the protei...
متن کاملBacterial type III secretion systems are ancient and evolved by multiple horizontal-transfer events.
Type III secretion systems (TTSS) are unique bacterial mechanisms that mediate elaborate interactions with their hosts. The fact that several of the TTSS proteins are closely related to flagellar export proteins has led to the suggestion that TTSS had evolved from flagella. Here we reconstruct the evolutionary history of four conserved type III secretion proteins and their phylogenetic relation...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2005
ISSN: 1537-1719,0737-4038
DOI: 10.1093/molbev/msi124